HSDB 7372
azadirachtin
CAS: 11141-17-6
Molecular Formula: C35H44O16
HSDB 7372 - Names and Identifiers
| Name | azadirachtin |
| Synonyms | AZATIN Bioneem KAYNEEM NeemAzal AZATIN(R) HSDB 7372 CCRIS 9142 CCIRS 9142 NSC 368675 Azadirachtin azadirachtin Azadirachtin A AZADIRACHTIN B Azadirachtin-A AZADIRACHTIN pure 3-TIGLOYL-AZADIRACHTOL EPA Pesticide Chemical Code 121701 |
| CAS | 11141-17-6 |
| InChI | InChI=1/C35H44O16/c1-8-15(2)24(38)49-18-12-19(48-16(3)36)32(26(39)43-6)13-46-21-22(32)31(18)14-47-34(42,27(40)44-7)25(31)29(4,23(21)37)35-20-11-17(30(35,5)51-35)33(41)9-10-45-28(33)50-20/h8-10,17-23,25,28,37,41-42H,11-14H2,1-7H3/b15-8-/t17?,18?,19-,20+,21?,22?,23-,25?,28-,29-,30+,31?,32+,33?,34?,35+/m1/s1 |
| InChIKey | TWGPOIQWWGNBKW-POEZYEDVSA-N |
HSDB 7372 - Physico-chemical Properties
| Molecular Formula | C35H44O16 |
| Molar Mass | 720.71 |
| Density | 1.51 |
| Melting Point | 159°C |
| Boling Point | 792.4±60.0 °C(Predicted) |
| Specific Rotation(α) | D -53° (c = 0.5 in CHCl3) |
| Flash Point | 244.841°C |
| Solubility | Soluble in methanol, ethanol, propanol, dimethyl sulfoxide and other polar organic solvents. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White to white-like powder or solid |
| Color | White to Pale Yellow |
| Merck | 13,896 |
| pKa | 9.78±0.70(Predicted) |
| Storage Condition | −20°C |
| Stability | Light Sensitive |
| Sensitive | Sensitivity to light and heat |
| Refractive Index | 1.623 |
| MDL | MFCD00083241 |
| Physical and Chemical Properties | Azadirachtin pure white non-crystalline material, light, heat unstable, soluble in methanol, ethanol, propanol, dimethyl sulfoxide and other polar organic solvents. |
HSDB 7372 - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3077 |
| WGK Germany | 3 |
| HS Code | 13021920 |
| Hazard Class | 9 |
| Packing Group | III |
HSDB 7372 - Nature
Open Data Verified Data
- azadirachtin and its analogs are a class of highly oxidized lemon compounds, and more than 10 major active compounds have been identified. Pure white non-crystalline material, light, heat unstable. Soluble in methanol, ethanol, acetone and dimethyl sulfoxide and other polar organic solvents. The appearance of the original drug was dark brown semisolid, and the relative density was 1. 1~1.3. The appearance of the preparation was Brown homogeneous liquid, the relative density was 0. 9~0. 98, and the pH was 4.5~7.5.
- dosage form single dose 0.3%, 0.32%, 0. 5% azadirachtin emulsifiable concentrate, 20% azadirachtin parent drug; 0. 8% Avi Azadirachta EC and 1% matrine azadirachtin EC.
Last Update：2024-01-02 23:10:35
HSDB 7372 - Preparation Method
Open Data Verified Data
azadirachtin was distributed in all parts of Azadirachta, but the highest content was in seed nucleus. The botanical insecticide can be obtained by extraction.
Last Update：2022-01-01 11:18:14
HSDB 7372 - Introduction
Crude extract of Nimes. Not used as a quantitative standard.
Last Update：2022-10-16 17:12:06
HSDB 7372 - Application
Open Data Verified Data
- a plant-derived insecticide, which has a strong antifeeding effect on insects. Lepidopteran pests are sensitive to them. Insects treated with azadirachtin (if) young molt extension and incomplete, body deformity, or death in molting. But the toxicity of azadirachtin is relatively low, the effect is slow, and the duration is short (5 ~ 7d), but it has a good role in the conduction.
- azadirachtin can be used for cotton, rice, corn, wheat, beans, flowers and other crops, prevention and control of the moth, Japanese golden turtle shell, tobacco Spodoptera exigua, Spodoptera litura, diamondback moth, the insect pests, such as the leaf fly, the grass armyworm, the desert locust, the African migratory locust, the corn borer, the rice brown planthopper, can also be used to control the stored grain pests.
Last Update：2025-08-19 16:24:40
HSDB 7372 - Safety
Open Data Verified Data
- rat acute oral LD50 was 1780 ~ 2150mg/kg, rabbit acute percutaneous LD50>2150mg/kg, low toxicity. It is safe for people, livestock, birds and honey peaks, does not affect the predatory and parasitic natural enemies, and is easy to degrade in the environment.
- 0.3% azadirachtin emulsion, looml× 40 bottles/piece.
Last Update：2022-01-01 11:18:15
HSDB 7372 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| botanical insecticide | azadirachtin is a botanical insecticide extracted from neem tree and is recognized as the best biological pesticide in the world today. It is characterized by high efficiency, low toxicity, broad spectrum, less interference to natural enemies, no obvious vertebrate toxicity and crop damage, and rapid degradation in the environment. Azadirachtin has the effects of anti-feeding, avoidance, absorption and inhibition of growth and development. It mainly acts on the endocrine system of insects to reduce the release of ecdysone; it can also directly destroy the epidermal structure or prevent the formation of epidermal chitin, interfere with respiratory metabolism, and affect the development of the reproductive system. The mechanism of action is special, the action location is many, and the pests are not easy to develop drug resistance. The content of azadirachtin in seeds is about 0.01%. Azadirachtin mainly exists in the seed nuclei of Neem and Neem, and even factors such as growth period and natural conditions will affect the content of active ingredients. Azadirachtin has a strong anti-feeding and insect growth regulation effect, and can be absorbed by plants. It has antifeedant activity at 0.1 mg/kg, and 0.35 mg/kg can make armyworm antifeedant. Azadirachtin has a strong anti-feeding effect on brown rice lice and can prevent oviposition. Safe for people, animals, etc. |
| toxicity | azadirachtin is safe for humans, animals, birds and bees, does not affect predatory and parasitic natural enemies, and is easy to degrade in the environment. |
| action characteristics | azadirachtin has many effects on pests, such as anti-feeding, anti-avoidance, poisoning and affecting insect growth and development, and has good internal absorption and conduction characteristics. The azadirachtin preparation is applied to the soil and can be absorbed and transported to the stems and leaves by the roots of cotton, rice, corn, wheat, broad beans and other crops, making the whole plant resistant to insects. The agent can effectively control gypsy moth, Japanese scarab, Spodoptera spout, Spodoptera, Spodoptera litura, Spodoptera litura, vegetable moth, leaf miner, meadow borer, desert locust, migratory locust, corn borer, rice brown planthopper and other pests. Usually 2 ~ 5kg of neem leaves are added to every 100kg of grain to control grain storage pests. |
| application | neem preparation can effectively control various pests, such as gypsy moth (Lymantria dispar), Japanese golden tortoise shell (Popillia japonica), Spodoptera robusta (Heliothis virescens), Spodoptera robusta (Heliothis zae), Spodoptera litura (Prodenia litura), Plutellamaculipennis moth (nubilalis), leaf miner (Agromyzidae), grass moth (Spodoptera frugiperda), desert locust (Schistocerca gregaria), African locust (Locusta migratoria migratorioidis), corn borer (Ostrinia), rice brown planthopper (nilaparvata lugens), etc. 0.1 ~ 1% nuclear ethanol extract spray is commonly used. Add 2 ~ 5kg of neem leaf powder per 100kg of grain to control grain storage pests. |
| control object | azadirachtin can control various crop pests. For the control of red spiders, rust spiders, aphids, leaf miner, whitefly on citrus crops; diamondback moth, cabbage worm, tobacco worm, cotton bollworm, tea green leafhopper, tea yellow thrips and various locusts on vegetables Good control effect. (1) using 0.3% azadirachtin emulsifiable concentrate 2.25~4.5g (active ingredient) per 100 square meters, mixed with water spray, can effectively control diamondback moth of cruciferous vegetables. (2) to control pests on citrus, it is recommended to use 1000~1300 times of 0.3% azadirachtin emulsifiable concentrate with an interval of 8~10 days. water spray can control red spiders, rust spiders, aphids, leaf miners and whiteflies on citrus crops. |
| precautions | (1) azadirachtin is a plant-derived insecticide with slow efficacy and should be used for prevention before larvae occur. Azadirachtin has a long efficacy. (2) It cannot be mixed with alkaline fertilizers and pesticides, nor can it be diluted with alkaline water. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:45:29
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